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Data of three studies of monitoring relating to l' use of the guaifenesin during the first quarter are available. 9- 11 qu codeine during pregnancy ' an increase in the d' risk; hernias inguinales was noted with the first use of quarter of the guaifenesin of 197 pairs of mother-child during perinatal Project. 4 of collaboration however, once analyzed codeine during pregnancy l' exposure of guaifenesin n' import when during the pregnancy this association n' was not significant. & amp; quot; The prednisone is preferred above the dexamethasone parce qu' it doesn& #039; intersection in T the placenta--d' other steroids will cross and include those employed to induce the foetal maturity of lung, & amp; quot; it noted during the meeting. More than 70 cough and of the products of cold codeine during pregnancy and influenza containing the dextromethorphan are enumerated in 2000 Physicians& #039; The reference of office for drugs without ordinance and complete dietetics, including several of the products of Robitussin, Vicks, and Triaminic. While these studies cannot eliminate a small risk for rare malformations, the results cancel almost the possibility that the DM is teratogenic important.
McEvoy GK, Miller J, and others, writers. Aylward M, Maddock |, and others extrapolating their results in a model nonmammalian with human, they proposed that the DM can have the same effects at l' man. One should carefully observe infants codeine during pregnancy supported with the mothers who received the substantial amounts of corticosteroids during the pregnancy for signs of hypoadrenalism. The retrospective review of diagram made take part six consecutive patients of the ultrasound-confirmed uterine leiomyomas, of the acute beginning of the abdominal pain, and tenderness directly above the leiomyoma. The patients received oral Mg of the prednisone 20 twice a day for 5 days or intramuscular injections of Mg of the dexamethasone 6 twice a day during 2 days. With the dimension codeine during pregnancy of l' sample larger we always did not find any obviousness than the rate of important malformations was increased in the babies exposed to the DM in the first quarter.
He is also director of the program of Motherisk with l' hospital for the ill children, Toronto, Dextromethorphan, the active substance in much coughs the cash and the cold remedies, is probably l' ingredient anticoughing more usually employed in the world.
D' elsewhere, Codeine during pregnancy there is approved infantile cough and produced cold which contains the DM. Compared with codeine, the capacity d' antitussive of the dextromethorphan is almost similar. 3, 4 acts of Dextromethorphan centrally in l' oblongata of medulla to raise the threshold of cough and is also known to act as so much Codeine during pregnancy qu' antagonist with the receivers of N-methyl-D-ASPARTATe (NMDA); however, it is not very clear if its activity of NMDA contributes to l' d' effect; antitussive since codeine does not bind to NMDA receptors. 1, 5 that Dextromethorphan is quickly absorbed gastro-intestinal area codeine during pregnancy (of GI) with the beginning of the suppression of cough within 15 to 30 minutes and the duration of l' effect between five to six hours. 1, metabolism 2 occurs in the liver by l' intermediary of the cytochrome P450 2D6 forming two metabolites inactive and a Codeine during pregnancy metabolite credit. During cough and the cold season, the question of if Robitussin® DM is sure for l' use during the pregnancy is often posed. Although codeine during pregnancy guaifenesin& #039; the mechanism of S of l' action n' is not completely known, it increases volume and decreases the viscosity of the respiratory area secretions. 14, 15 that Guaifenesin well-is absorbed area of GI with roughly 60% of guaifenesin hydrolized in l' obviousness codeine during pregnancy of blood. 14Peer-reviewed supporting l' effectiveness of the guaifenesin because one expectorant is l' study limited. 15 one evaluating l' effectiveness of the guaifenesin in the patients presenting bronchitis found qu' it study d' ineffective. 16 has in the second place in the patients presenting of cold noted that the guaifenesin subjectively thinned mucus; however, the amount of treatment of guaifenesin was twice where the dose. 17Guaifenesin recommended has a molecular weight of 198 daltons, indicating the possible placental transfer. Since the data d' effectiveness supporting l' use of the guaifenesin as expectorant are limited, l' use dextromethorphan-only d' one suppressant of cough (see that table 1) should be considered. During lactation, a little DM write the mother's milk but don& #039; T exert harmful effects on the looking after babies.